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Drug Pipeline Review Therapy area: Myocardial Infarction40–50 pages · PDF + Excel tracker

Myocardial Infarction Drug Pipeline: 24 Assets by Phase

Myocardial Infarction pipeline: 24 drug candidates in clinical development, 11 in Phase III, from 23 sponsors. Data as of 4 Oct 2026.

Pipeline Terminal Myocardial Infarction Data as of 4 Oct 2026
Candidates in development 24assets Desk-reviewed How this number is madeEvery drug named in an interventional trial, merged across code, generic and brand names, with a live or recent industry trial. Placebo and comparator arms excluded.
Phase III 1146% of pipeline Registry How this number is madeCandidates whose highest phase in a live or recent trial is Phase III (Phase II/III counts as Phase II).
Phase II 938% of pipeline Registry
Phase I 417% of pipeline Registry
Sponsors 23top 5 hold 25% Registry How this number is madeCompanies credited with at least one candidate: the lead sponsor on most of that candidate's industry trials.
Registered trials 440177 running Registry How this number is madeInterventional trials on ClinicalTrials.gov for the conditions in scope, updated since 4 Oct 2021.
Readouts in 12 months 7Phase II or later Sponsor dates How this number is madeCandidates with a registered primary completion date in the next 12 months. Dates are the sponsor's own and often move.
Trials with US sites 7417% · Europe 35% Registry How this number is madeTrials with at least one site in the United States; Europe is the EU/EEA, the UK and Switzerland. A trial counts in every region where it has a site.

Candidates by highest phase reached

Phase I4
Phase II9
Phase III11

Next registered primary completions, Phase II or later

CandidatePhasePrimary completion
ZiltivekimabPhase IIIJan 2027 (est.)
OrticumabPhase IIFeb 2027 (est.)
EmpagliflozinPhase IIIMar 2027 (est.)

Candidates in development by lead sponsor

Novartis Pharmaceuticals2
4TEEN4 Pharmaceuticals GmbH1
Implicit Bioscience1
Shanghai CureGene Pharmaceutical Co., Ltd.1
CSL Behring1

Phase II and III primary completions per quarter

Q4 20260
Q1 20273
Q2 20272
Q3 20272
Q4 20270
Q1 20280
Q2 20280
Q3 20282

Answers at a glance

  • 11 of 24 myocardial infarction candidates (46%) are in Phase III.
  • Novartis Pharmaceuticals runs the largest myocardial infarction pipeline, with 2 candidates.
  • 7 readouts are due in 12 months; the next is Ziltivekimab in Jan 2027.
  • 103 trials are recruiting patients now; 17% of all trials have a US site and 35% a European one.
24 candidates440 trials77 countriesData as of 4 Oct 2026Next refresh by 2 Jan 2027
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Edition: data as of 4 Oct 2026 Next refresh: by 2 Jan 2027 Change: First edition

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A sample of the Myocardial Infarction Pipeline Review: the full chapter list, the tracker columns and two asset profiles from the report. The Research Desk reviews your request and emails it, usually within one business day.

Myocardial Infarction has 24 drug candidates in active clinical development, of which 11 are in Phase III, 9 in Phase II and 4 in Phase I, according to Douglas Insights' count of 440 interventional trials registered on ClinicalTrials.gov (data as of 4 Oct 2026).

The myocardial infarction drug pipeline is the set of medicines that sponsors are still testing in people for this condition: each candidate is counted once, at the highest phase it has reached in a running or recently completed trial. Medicines already on the market and studied only in Phase IV trials are kept out of the count.

How many myocardial infarction drugs are in each phase of development?

Douglas Insights counts 11 myocardial infarction candidates in Phase III, 46% of the 24 assets in development; Phase II holds 9 and Phase I holds 4.

Phase I4Phase II9Phase III11
Candidates by highest phase reached. Source: Douglas Insights from ClinicalTrials.gov, data as of 4 Oct 2026.
Phase (highest reached)AssetsShare of pipeline
Phase III1146%
Phase II938%
Phase I417%
Total24100%

Phase I/II candidates sit in the Phase I row and Phase II/III candidates in the Phase II row, so each myocardial infarction asset appears in exactly one row. The 177 trials still recruiting or running carry 40% of the 440 registered trials in scope.

Which approved myocardial infarction medicines are still in trials?

8 medicines already on the market are still being tested in myocardial infarction Phase IV trials; Ticagrelor has the most, with 24 registered trials.

MedicineLead sponsorRegistered trials
TicagrelorAstraZeneca24
AspirinSeveral sponsors18
ClopidogrelShanghai CureGene Pharmaceutical Co., Ltd.15
RivaroxabanBayer13
EvolocumabAmgen9
Recombinant staphylokinaseSupergene, LLC4
PrasugrelDaiichi Sankyo Taiwan Ltd., a Daiichi Sankyo Company2
rhTNK-tPACSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.2

Post-approval myocardial infarction trials test new doses, new patient groups and head-to-head comparisons. They set the standard of care that every candidate in development will be measured against, so the paid review profiles each one.

How many myocardial infarction trials are recruiting patients now?

103 myocardial infarction trials are recruiting patients and 43 more have not started recruiting yet, out of 440 interventional trials in scope; together they make up 33% of the trial base.

Registry statusTrialsShare
Completed17039%
Recruiting10323%
Status not verified5513%
Not yet recruiting439.8%
Active, not recruiting286.4%
Terminated225.0%
Withdrawn163.6%
Enrolling by invitation30.7%

Terminated, suspended and withdrawn myocardial infarction trials stay in the trial base so that a stalled programme is visible, but a candidate whose only trials stopped is no longer counted as in development.

Which companies lead the myocardial infarction pipeline?

Novartis Pharmaceuticals leads the myocardial infarction pipeline with 2 candidates; the top 5 sponsors hold 25% of the 24 assets, and 23 sponsors run at least one.

SponsorAssets in developmentShare
Novartis Pharmaceuticals28.3%
4TEEN4 Pharmaceuticals GmbH14.2%
Implicit Bioscience14.2%
Shanghai CureGene Pharmaceutical Co., Ltd.14.2%
CSL Behring14.2%

Industry sponsors lead 96 of the 440 myocardial infarction trials (22%); universities, hospitals and public funders lead the rest. A sponsor is credited with an asset when it is the lead sponsor on most of that asset's industry trials.

Which drug types and mechanisms dominate the myocardial infarction pipeline?

Mechanism and drug-type classification for the 24 myocardial infarction candidates is done by the research desk asset by asset, each with a cited source, and is published in the paid review together with the white-space map.

What myocardial infarction trial readouts are coming next?

7 myocardial infarction candidates in Phase II or later have a registered primary completion date in the next 12 months; the next three are below, each linked to its registry record.

CandidateSponsorPhasePrimary completionRegistry
ZiltivekimabNovo Nordisk A/SPhase IIIJan 2027 (estimated)NCT06118281
OrticumabAbcentraPhase IIFeb 2027 (estimated)NCT06927739
EmpagliflozinBoehringer IngelheimPhase IIIMar 2027 (estimated)NCT05879276

Primary completion is the date a sponsor expects the last patient to finish the main measurement, so data usually follow within months. Dates marked estimated are the sponsor's own forecast on the registry and often move.

How many myocardial infarction readouts fall in each quarter?

9 myocardial infarction candidates in Phase II or later reach registered primary completion over the next eight quarters, with the most, 3, due in Q1 2027.

QuarterPhase III readoutsPhase II readoutsTotal
Q4 2026000
Q1 2027213
Q2 2027022
Q3 2027112
Q4 2027000
Q1 2028000
Q2 2028000
Q3 2028022

Each candidate is counted once, at its next readout. The paid catalyst calendar names every readout with its trial, sponsor and design, adds filings and regulatory decisions, and runs 24 months ahead.

Which countries host the most myocardial infarction trials?

China hosts the most myocardial infarction trials, with sites in 78 of the 440 studies (18%); trials in scope run in 77 countries in all.

CountryTrials with a siteShare of trials
China7818%
United States7417%
France5412%
Canada4811%
Poland439.8%
Spain439.8%
Netherlands368.2%
Germany347.7%

A multinational myocardial infarction trial is counted once in every country where it has a site, so the shares add up to more than 100%. Country spread shows where sponsors are building the evidence that regulators in each market will ask for.

Where are myocardial infarction drugs being tested?

74 of the 440 myocardial infarction trials (17%) have a site in the United States, 155 (35%) in Europe and 78 (18%) in China; 15 of the 24 candidates in development are tested in the US.

RegionTrials with a siteShare of trialsCandidates testedRegulator
United States7417%15FDA
Europe (EU/EEA, UK, Switzerland)15535%15EMA, MHRA, Swissmedic
China7818%9NMPA
Japan143.2%5PMDA
Rest of world18342%16national regulators

Each region's trials are the evidence its regulator will review: the FDA in the United States, the EMA (with the MHRA and Swissmedic) in Europe, the NMPA in China and the PMDA in Japan. A multinational myocardial infarction trial counts once in every region where it has a site, so the shares add up to more than 100%. A candidate tested only outside the US and Europe is often a licensing opportunity for sponsors in those markets.

What has changed in the myocardial infarction pipeline since the last update?

This is the first edition of the myocardial infarction pipeline count, dated 4 Oct 2026. The next refresh is due by 2 Jan 2027, and each refresh lists the assets that entered, advanced or dropped out.

How does Douglas Insights count the myocardial infarction pipeline?

Douglas Insights read 440 interventional trials registered on ClinicalTrials.gov for the conditions "myocardial infarction", "acute myocardial infarction" and updated since 4 Oct 2021, then grouped every drug or biologic named in them into 24 unique candidates.

  1. Code names, generic names and brand names of the same molecule are merged into one candidate, and every merge is reviewed by the research desk.
  2. A candidate counts when it has a trial that is recruiting, running, or completed in the last 24 months, and at least one industry-sponsored trial.
  3. Its phase is the highest phase among those trials; placebo, standard-of-care and comparator arms are not candidates.
  4. Each figure on this page is drawn from one frozen dataset that passes ten checks before release, and the owner approves every edition.

Read the full approach on the research methodology page, or browse other Pharmaceuticals research.

What does the Myocardial Infarction Pipeline Review include?

The Myocardial Infarction Pipeline Review covers all 24 candidates in an Excel tracker and profiles the leading 24 in a 40–50 page report, ending with the research desk's ranked view of the candidates most likely to win.

11 chapters40–50 pages25 asset profilesExcel tracker of all 24 candidates
01Executive summary and our call2–3 pp

The pipeline on one page and the desk's verdict on where myocardial infarction treatment is heading.

  • Pipeline size and phase mix
  • The three calls that matter
  • What changed since the last edition
02Disease and unmet need3 pp

Who is treated today, what current therapy leaves unmet, and how regulators judge new medicines.

  • Patient population and diagnosis
  • Treatment guidelines and gaps
  • Regulatory endpoints
03Approved therapies3 pp

The marketed medicines every myocardial infarction candidate will be measured against.

  • Marketed medicines and their sponsors
  • Post-approval trials
  • The bar a new entrant must clear
04Pipeline at a glance4 pp

Every candidate counted by phase, drug type, sponsor and country.

  • Assets by phase and drug type
  • Sponsors by size of pipeline
  • Trial footprint: US, Europe, China, Japan
05Mechanism landscape and white space5 pp

Which mechanisms are crowded and which no sponsor has entered.

  • Mechanism classes and crowding
  • Classes with no candidate yet
  • Differentiation by route and dosing
06Key asset profiles12–15 pp

The leading 25 candidates, one profile each, every claim linked to a source document.

  • Design and endpoints of the pivotal trials
  • Data to date, with sources
  • Next readout and the risk to it
07Catalyst calendar3 pp

Readouts, filings and regulatory decisions 24 months ahead.

  • Readouts by quarter
  • Filings and regulatory decisions
  • Date confidence for each event
08Deals and partnering3 pp

Who is licensing, buying and partnering in myocardial infarction, and on what terms.

  • Licensing and M&A in the area
  • Deal terms where disclosed
  • Sponsors open to partnering
09Sponsor landscape3 pp

Large pharma against biotech, and how concentrated the pipeline is.

  • Pipeline share by sponsor
  • Sponsor-by-phase matrix
  • New entrants since the last edition
10Our call: winners, risks, opportunities3–4 pp

The candidates most likely to win, ranked, with the reasoning and evidence.

  • Ranked candidates
  • Risks that could change the order
  • Openings for new entrants and investors
11Methodology and source log2 pp

How the count is built and every document behind it.

  • How candidates are counted and merged
  • Every source document listed
  • The ten quality checks

Ways to buy the Myocardial Infarction review

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Frequently asked questions about the myocardial infarction pipeline

How many drugs are in the myocardial infarction pipeline?

24 drug candidates are in active clinical development for myocardial infarction, with 11 in Phase III, per Douglas Insights (data as of 4 Oct 2026).

Which company has the most myocardial infarction drugs in development?

2 candidates make Novartis Pharmaceuticals the largest myocardial infarction pipeline sponsor, out of 23 sponsors counted by Douglas Insights.

When is the next myocardial infarction trial readout?

Jan 2027 is the registered primary completion of the Phase III trial of Ziltivekimab (NCT06118281), the next myocardial infarction catalyst in Douglas Insights' calendar.

How many myocardial infarction trials run in the United States and Europe?

74 myocardial infarction trials have a US site and 155 a European site, out of 440 registered trials counted by Douglas Insights (data as of 4 Oct 2026).

How often is the myocardial infarction pipeline count updated?

90 days is the refresh cycle; this edition uses registry data as of 4 Oct 2026 and the next is due by 2 Jan 2027.

Research & citation

This review was researched, written and reviewed by the Douglas Insights Research Desk under the Douglas Insights editorial standards. Material errors are logged in the corrections log. No section is sponsored.

Cite this page Douglas Insights (2026). Myocardial Infarction Drug Pipeline, data as of 4 Oct 2026. https://www.douglasinsights.com/pipeline/myocardial-infarction/