Type 2 Diabetes Drug Pipeline: 220 Assets by Phase

How many type 2 diabetes drugs are in each phase of development?

Douglas Insights counts 73 type 2 diabetes candidates in Phase III, 33% of the 220 assets in development; Phase II holds 48 and Phase I holds 99.

Phase I/II candidates sit in the Phase I row and Phase II/III candidates in the Phase II row, so each type 2 diabetes asset appears in exactly one row. The 495 trials still recruiting or running carry 28% of the 1,738 registered trials in scope.

Which approved type 2 diabetes medicines are still in trials?

17 medicines already on the market are still being tested in type 2 diabetes Phase IV trials; Semaglutide has the most, with 167 registered trials.

Post-approval type 2 diabetes trials test new doses, new patient groups and head-to-head comparisons. They set the standard of care that every candidate in development will be measured against, so the paid review profiles each one.

How many type 2 diabetes trials are recruiting patients now?

252 type 2 diabetes trials are recruiting patients and 115 more have not started recruiting yet, out of 1,738 interventional trials in scope; together they make up 21% of the trial base.

Terminated, suspended and withdrawn type 2 diabetes trials stay in the trial base so that a stalled programme is visible, but a candidate whose only trials stopped is no longer counted as in development.

Which companies lead the type 2 diabetes pipeline?

Novo Nordisk A/S leads the type 2 diabetes pipeline with 16 candidates; the top 5 sponsors hold 25% of the 220 assets, and 101 sponsors run at least one.

Industry sponsors lead 960 of the 1,738 type 2 diabetes trials (55%); universities, hospitals and public funders lead the rest. A sponsor is credited with an asset when it is the lead sponsor on most of that asset's industry trials.

Which drug types and mechanisms dominate the type 2 diabetes pipeline?

Mechanism and drug-type classification for the 220 type 2 diabetes candidates is done by the research desk asset by asset, each with a cited source, and is published in the paid review together with the white-space map.

What type 2 diabetes trial readouts are coming next?

41 type 2 diabetes candidates in Phase II or later have a registered primary completion date in the next 12 months; the next three are below, each linked to its registry record.

Primary completion is the date a sponsor expects the last patient to finish the main measurement, so data usually follow within months. Dates marked estimated are the sponsor's own forecast on the registry and often move.

How many type 2 diabetes readouts fall in each quarter?

68 type 2 diabetes candidates in Phase II or later reach registered primary completion over the next eight quarters, with the most, 15, due in Q4 2026.

Each candidate is counted once, at its next readout. The paid catalyst calendar names every readout with its trial, sponsor and design, adds filings and regulatory decisions, and runs 24 months ahead.

Which countries host the most type 2 diabetes trials?

United States hosts the most type 2 diabetes trials, with sites in 552 of the 1,738 studies (32%); trials in scope run in 92 countries in all.

A multinational type 2 diabetes trial is counted once in every country where it has a site, so the shares add up to more than 100%. Country spread shows where sponsors are building the evidence that regulators in each market will ask for.

Where are type 2 diabetes drugs being tested?

552 of the 1,738 type 2 diabetes trials (32%) have a site in the United States, 407 (23%) in Europe and 388 (22%) in China; 77 of the 220 candidates in development are tested in the US.

Each region's trials are the evidence its regulator will review: the FDA in the United States, the EMA (with the MHRA and Swissmedic) in Europe, the NMPA in China and the PMDA in Japan. A multinational type 2 diabetes trial counts once in every region where it has a site, so the shares add up to more than 100%. A candidate tested only outside the US and Europe is often a licensing opportunity for sponsors in those markets.

What has changed in the type 2 diabetes pipeline since the last update?

This is the first edition of the type 2 diabetes pipeline count, dated 3 Oct 2026. The next refresh is due by 1 Jan 2027, and each refresh lists the assets that entered, advanced or dropped out.

How does Douglas Insights count the type 2 diabetes pipeline?

Douglas Insights read 1,738 interventional trials registered on ClinicalTrials.gov for the conditions "type 2 diabetes" and updated since 3 Oct 2021, then grouped every drug or biologic named in them into 220 unique candidates.

1. Code names, generic names and brand names of the same molecule are merged into one candidate, and every merge is reviewed by the research desk.
2. A candidate counts when it has a trial that is recruiting, running, or completed in the last 24 months, and at least one industry-sponsored trial.
3. Its phase is the highest phase among those trials; placebo, standard-of-care and comparator arms are not candidates.
4. Each figure on this page is drawn from one frozen dataset that passes ten checks before release, and the owner approves every edition.

Read the full approach on the research methodology page, or browse other Pharmaceuticals research.

Frequently asked questions about the type 2 diabetes pipeline

Research & citation

This review was researched, written and reviewed by the Douglas Insights Research Desk under the Douglas Insights editorial standards. Material errors are logged in the corrections log. No section is sponsored.

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